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The efficacy population in demo B constituted members who acquired all drug doses and had chilly pressor efficacy info from all 3 segments. A sensitivity Assessment was done by conducting the analyses to the ITT, for every-protocol, and efficacy populations as defined. All final results presented are with the ITT population; Unless of course usually specified, success within the for each-protocol and efficacy inhabitants analyses supported People for your ITT populace. The security populace bundled all patients who gained study drug. All protection analyses were being done on the security population.

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